Never thought of this, you're not wrong.

On the other side her dying because she lost the will to life... is kind of a good explanation for an unlikely death in such an advanced civilization.

Obviously they could simply keep her alive despite any actual medical condition. So what else could she die of... except for a spiritual (I don't know a better description) reason.

Kind of a "so bad it's actually good" explanation.

I know we're dealing with human aliens, but there is actually a thing called takotsubo cardiomyopathy, also known as "broken heart syndrome", where your heart weakens as a result of emotional trauma.

It is rarely fatal, but deaths have occurred as a result of it.

It was explained in one of the comics that she died because Vader was unknowingly siphoning her life energy to keep himself alive.

The scene is still dumb and definitely needed a better explanation but it is what it is at this point

The only head canon that makes sense is that Palpatine drained her life force in order to bring Vader back from the dead.

The only head canon that makes sense to me is that Palpatine used Padme's life force to bring Vader back from the dead.