RE: Audio stuff I switched to bitwig long before I switched to Linux. Having familiarity with a DAW that ran natively was awesome; I also had a lot of plugins that ran as windows only VSTs. Yabridge + Wine was the answer.
You do have to downgrade wine to an older version (but this also helps you learn some Linux stuff) and works fairly well. I can even run omnisphere through yabridge (I do have a wild desktop tho so maybe not. the best point of comparison).
Mint is the first distro I used and most everything was really easy for getting audio stuff up and running quickly. I'm now using Garuda which I mostly like; there are issues that I'm still trying to work out.