First confirmed sex. It's likely to already have happened a few times. The Soviet Union even sent a husband/wife couple at one point, unless I'm misremembering.
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What the problem with sex in space?
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The concerns of the effects of gravity, especially in the very early stages.
Also concerns with the higher radiation exposure, again especially in the early stages where most development is happening at the cellular level.
And what those (and more) would mean from a longterm standpoint. These are also concerns for longterm colonies on other planets (such as Mars) which have higher radiation exposure due to Mars' lower magnetic fields and lower gravity.
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