The initial prologue cutscene in Okami. It's about fifteen minutes and unskippable. But, the lore being delivered by textbox, you can't just do something else because you have to press a button to advance the text.
I love that game dearly. If I had to pick one game as my most favourite of favourites, this would be it. But please, let me skip the first fifteen minutes once I, iunno, progressed beyond the tutorial.