Is there a reason you're suspecting it wouldn't work? I've got a 4-disk ZFS array running on a ThinkCentre 715 via 3 USB 3.0 ports. Works great. I assume a framework board in the CM case should perform even better given its USB ports are better.
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That would be possible but IMO it would be better to sell that fairly new mainboard. I would use an older machine you have laying around or a Raspberry Pi for that, as you probably don't need the computing power of the FW for it.
I'm using my 11th gen mainboard as a proxmox host, but the USB NIC I have is very unreliable. I ordered a M.2 intel based NIC and hopefully this will work better.
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