Factoring in marketing costs and the theaters taking their cut of the profits, Megalopolis would need to make at least $300 million to break even. I think it's safe to say that's not happening.
It would have been THE worst opening for a $100 million movie ever, had it not been for Pluto Nash's horriffic opening 22 years ago.
Having said all that I would like to see it, just don’t need to go to the theater for this one.
From what little I've heard, there's a 4th-wall-breaking scene that involves one of the characters interacting with an audience member (the theater apparently has someone come in and participate). So if nothing else, I guess you could see it in theaters for the novelty?