I remember in Revenge of the Sith, when the actor playing Vader yells "nooooooooo", at what is supposed to be the emotional climax of the trilogy, the theater roared in laughter.
In the recent Ferrari movie, there's a scene with one of the legendary racing drivers. He's in the lead at the big race and he just needs to bring it home for the win. He's got a big smile, the shots are serene, the music is swelling. Then suddenly, he wrecks super violently and crashes into a crowd of people. I absolutely lost it. I was the only one.