I've just swept and mopped. Once the floor dries, I could easily go sweep again and turn up more dust and dirt. If I were to mop again, I'm almost certain the water in my bucket would be filthy. It feels like it's never actually clean.
Beyond that, there's dusting, cleaning windows, sinks, countertops, bathrooms, and probably things I don't even consider. How do you all stay on top of these things?
You're never going to be sterile; good enough is good enough.
Keep an abundance of cleaning supplies. Soaps and rags in the kitchen and the bathroom. Think about investing in a vacuum and a carpet cleaning machine. Edit = Also get more trash bins. One for the kitchen, one for the desk, one by the coffee table, one for the bathroom.
Some people find it easier to do one big push where they clean the whole house in one session; other folks like to do a little bit every day. Figure out which type you are.
Also, check and see what cleaners charge in your area. It might be worth it to have a pro come in and do the work for you. Figure out what your leisure time is worth to you and then compare.