Wool makes a massive difference and it isn't even close.

For one, it has an uncanny ability to wick away moisture from the surface of your skin, away from your body. As it reaches the outside, it more easily evaporates away and minimizes the amount of absorbed and thus odorous sweat.

Skin also maintains "comfort" at a larger range of temperatures with wool. I have thicker wool socks I wear in summer with tall leather work boots and after 12-16 hours straight of wear my socks typically have virtually no smell and they're dry to the touch. Synthetic socks like Dickies absorb the sweat and cause the fibers to break down terribly. You end up with crusty, worthless socks.

Lanolin

Not quite like changing undies, which cover open orifices.