I'm not on Arch, I'm on Gentoo, but I'm using Flatpak, so this should apply to you too.
Just get Bottles.
I've tried it on:
- Assassin's Creed 1
- Assassin's Creed 2
- Nier Automata
- Nier Replicant
- Crash Bandicoot
- Dishonored
... and probably some other titles I can't recall on top of my head.
The gotcha is that you may have to install the right library dependencies (e.g. DVDX, .NET, Mono, Redistributable C++, probably fonts), which can be done on the Bottles.