Breaking bad
SPOILERS
Specifically this was 2 episodes away from the end of the show but I just could not handle it. It was just so depressing. Family and friends being murdered, almost everything walt has worked for squandered, Skyler trying to kill him, having to steal the child and Skyler's anguish. Man it was just too much to handle because EVERYTHING was just crumbling and collapsing in on itself.
What made it cut so deep is that Walter tried to provide for his family, so they could have a good life and for a time was extremely successful. After multiple missteps, some of his family is murderer or they hate him, trying desperately to remove him from their lives and resent his very existence. While Walter still loved them, he realized his and his family's was utterly ruined. The second hand crushing and crippling guilt was too painful to bear.
Waler's psychopathy and coldness was also building up at this point, killing, using and manipulating a lot of people. He began with good intentions but directly and indirectly ended and ruined countless people's lives.