CSGO - yes. Path of exile - probably, IDK. Destiny 2 - Yes, but you have to install windows. It has 1 usb-c port that you can plug in any pc dock. Other than that itβs a handheld PC with Linux pre-installed and custom UI to launch games with a controller. It can play most windows PC games.
Check protondb.com if you want to know compatibility for a particular game.