I'm someone who gets slapped in the face over and over with a large, wet trout by RNG, everywhere I go. And BP felt brutal until I started noticing some draft spawning rules. Decided to cheat a little and looked that up, and that allowed me to take advantage of the system to help me get almost all the way to the final secrets of the game at the time (way past Room 46). That, along with the various permanent upgrades and tips on gem management the game gives you.

I've otherwise been punished by red rooms even when those rooms are made Rare. Still happens after learning that mechanic too, and I still have runs where I have to end the day after just going 3 ranks deep, but the game feels just a bit more managable overall.