His response was about this season’s unusual targeting of the administration.

It isn't unusual. South Park has dedicated an episode or three to mocking US and foreign politicians, NGOs, and popular figures going back to their first season. This feels like the old "When Did Star Trek Get Political?!" whine.

it is unusual for the show to focus so much on the current administration of the US

That hasn't been true in decades. The episode About Last Night... pillared both '08 presidential hopefuls. A year before that The Snuke bashed Presidential hopeful Hillary Clinton, a character who has appeared in no less than fifteen episodes. On the flip side, Bush Jr got an appearance in thirteen episodes, starting as early as 2001. And they weren't afraid of taking some deeper cuts, too. FFS, Gary Condit appeared three times.

The early seasons were largely an expression (abet, significantly more abstract relative to any sitting politician) of Matt and Trey's own libertarian brand of politics - including their takes on gay marriage, gun ownership, climate change, drug policy, state censorship, the anti-muslim/pro-war post-9/11 politics. And they tip-toed around naming names until they'd built up a brand.

But to imply the show wasn't critical of contemporary administrative policies, you really need to squeeze your eyes shut and refuse to read some pretty naked allegories and references.