Oh, now you're stretching. Bob isn't "plus size" he's meant to look like a bodybuilder who let himself go (and gets back into shape once the societal restraints on his self-actualization are removed). The scenes where his environment is shown to be too small for his stature are a visual representation of "normal" life holding him back from his natural greatness, not a rendition of the struggles of plus sized people.
I mean, Dash and ADHD works better, but it has the same problem as Vi's anxiety in that he gets better by being himself and doing what he was meant to do and "being the best he can be", which is what he complains his mom is not letting him do. If you want to read the kids' powers as mental health issues actualized then I can't be on board with how the denouement's return to a modified normalcy presents their new situation. They didn't work to get adjusted, they didn't need help or therapy or support, just to be set free to self-actualize.
I don't think that's the idea, beyond the superficial (the kids' mental health is played as growing pains or inherent characteristics of childhood, if anything), but if it was it'd be more problematic than the alternative.
I also take issue with the idea that white suburban middle class is "a cultural image we're familiar with" and so suitable to serve as a projection of a minority allegory. I mean, no, white suburban middle class isn't default human. If you set out to make an allegory about middle class you don't come at it from that premise, that'd be... bad. Again, I think the objectivist read is actually less problematic there.
On that it again helps to look at similar media that DOES use superpowers as a minority allegory. Yeah, the X-Men work as a metaphor for that, and you do see it transposed to white middle class. X2's "Have you tried NOT being a mutant" scene comes to mind. But they are also presented on the run from authorities, living in the sewers, looking visibly different to non-mutants and being shunned on sight and in all sorts of other situations analogous to real world discrimination. The Incredibles does very much not. Suburban middle class life is stiffling in that very 90s way where it's fine but it's not the self-realization that special people like the Parrs were meant for, so it makes the men in particular feel restless and frustrated.
The Incredibles is a bit of an anti-Fight Club, now that I think of it. Which is weird to think about, but it fits. Both get interpreted backwards often, too.