I think when people imply we might suddenly learn that we were completely wrong about everything they are actually talking about how fast science seems to evolve these days, at the very least the public's understanding of science.

I have coworkers with who i can talk about 3+ dimensions, quantum mechanics, time travel, uap and while none of us are experts in any of those fields it no longer feels like we should be wearing a tinfoil hat simply for being fascinated by such topics because we now understand these are real (nuanced) scientific topics and not "something from the movies".

It's okay to be 'wrong' in science within the observable world, much of Newton's theories were rendered nearly obsolete by Einstein, but Newtonian physics was "good enough" until technology improved, and was "good enough" for most of his generation and later:

"While general relativity has been more precise, Newtonian gravity is still incredibly accurate and can be used for simpler situations. General relativity uses complex calculus that makes it difficult to compute. But Einstein has opened up the world to more complex physics, like black holes and gravitational waves that continue to develop our understanding of the universe. " https://imagine.gsfc.nasa.gov/educators/programs/cosmictimes/educators/workshops/docs/InquiringIntoNatureUniverse/Newton_Einstein_FactCards.pdf

Epistemology allows for us to work within the framework of knowledge we currently have until something better is proven to be the case.

It's happened before

Well, cutting edge science currently suggests spacetime is an illusion, so I think antireal science might have some interesting places to go as far as FTL travel. But we don't need FTL travel to talk to new forms of life, because there are sentient nonhuman species on Earth, and they speak English.