PiHole and AdGuard are both easy to setup servers for network wide DNS blocking. (Homenetworking)

NextDNS is an external entity that allows you to setup DNS blocking on devices that support DoT, DoH, and occasionally plaintext DNS. (For your phone and other mobile devices)

iPhones and Androids both support DoT while Firefox (and likely most modern browsers) supports DoH.

If you don't want to rely on an external entity, you could use a wire guard split tunnel to block your ads away from your home network. Additionally you can set up a VPS and self host your DNS server there.

If you can block all DNS traffic on you router, you can them redirect it to your own DNS server.

And PiHole seems to be the one many people use for that. Lots of guides for it, pre-made list on what to block etc.

Not the person you asked, but also a nextdns user: I have a light (in terms of blocking) profile on my router (set up via a DoH address, but DoT and traditional DNS are also possible). Then I have a much more strict profile I use just for my phone and laptop with more serious blocking, including porn filters (recovering addict). I set these up per-device, but later I learned I can do it in Tailscale (which I did).