Proton isn't meant to be run outside of Steam at all. If you are running games in Lutris you need to use the "lutris-GE-Proton8-14" you can find in the Lutris wine version manager. There is actually a huge bold disclaimer about that on the proton-ge-custom repo I linked in my last comment. Proton (and Steam) bundles a bunch of libraries together while Lutris uses whatever versions your system has installed.
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