[–] 4 points 11 months ago* (last edited 11 months ago) (2 children)

At least 40% of human cancers are associated with aberrant ERK pathway activity (ERKp).

https://www.nature.com/articles/s41698-024-00554-5

ERK expression is critical for development and their hyperactivation plays a major role in cancer development and progression.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7027163/

Prolonged oxidative stress contributes to cancer initiation and progression through several biological mechanisms.

https://biologyinsights.com/oxidative-stress-and-cancer-whats-the-connection/

Oxidative stress, characterized by the production of reactive oxygen species (ROS) within cells, plays a critical role in the development of cancer by affecting genomic stability and signaling pathways within the cellular microenvironment.

https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01398-5

Inflammation predisposes to the development of cancer and promotes all stages of tumorigenesis.

https://pmc.ncbi.nlm.nih.gov/articles/PMC6831096/

  • source
  • parent
  • context
  • [–] 3 points 11 months ago* (last edited 11 months ago)

    It's releasing a high amount of micro and nano plastics, and those are linked to different health issues including cancer.

    https://www.sciencedirect.com/science/article/pii/S0048969724027232

    our findings suggest that PTFE-MPs-associated toxicity may be specifically linked to the activation of the ERK pathway, which ultimately induces oxidative stress and inflammation.

    https://pubmed.ncbi.nlm.nih.gov/37419366/

  • source
  • parent
  • context
  • [–] 6 points 11 months ago (4 children)

    It's releasing a high amount of micro and nano plastics, and those are linked to different health issues including cancer.

    https://www.sciencedirect.com/science/article/pii/S0048969724027232

    our findings suggest that PTFE-MPs-associated toxicity may be specifically linked to the activation of the ERK pathway, which ultimately induces oxidative stress and inflammation.

    https://pubmed.ncbi.nlm.nih.gov/37419366/

  • source
  • parent
  • context
  •  

    MX Linux, Xfce 4.18

    Closing the laptop lid suspends the system, opening it resumes it, but the screen is black. I'm guessing it's related to powerup because suspending through the logout menu and systemctl suspend both work as expected. When it's black, switching to a different tty works, as well as C-M-Backspace to logout.

    Same results with both lightdm and sddm, when replacing suspend with hibernate, and I've tried a few solutions like disabling lock on sleep.

    Seems like this issue has been around for years, but had a whole bunch of different causes since every other thread has a different solution.

    XFSETTINGSD_DEBUG=1 xfsettingsd --replace --no-daemon > /tmp/xf.log 2>&1

    ps -ef | grep -E 'screen|lock'

    xfconf-query -c xfce4-power-manager -lv

    dmesg, cleared it before trying to suspend

    updates:

    I'm not seeing a black screen, instead it turns on the display and then turns it off.

    Additionally, I tried closing and opening the lid a few times, and it woke up correctly.

    I tried it in i3wm with the xfce power manager to suspend after closing the lid. It woke up correctly 10 times in a row.

    Solution: start an xrandr config and the monitor turns back on.

    view more: next ›