Well, that's comical. My post didn't save what I wrote.
spoiler
The ending of Priyet's EX story still hits like a truck and has to be my favorite and the most heavy hitting, but Louise (shocker with my PFP and username), the God Box, Ending D of Replicant, the last conversation in Ending D of Drakengard 3, and the twins at the Tower entrance are all very close contenders.
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