Progesterone significantly improved my quality of sleep. I found that it doesn't make me sleepy by itself, but if I'm already sleepy, it makes it easier to fall asleep (which is great bc I have horrible insomnia). Yes, I do take it rectally at night. But as with any medication, it's going to have different effects on different people. For me, taking it takes less than 5 minutes, so it's easy to squeeze into my nightly routine (more details below on how I do it quickly). In reality, when you take it is not going to really matter. People who have bad dreams on progesterone often decide to take it in the morning instead, for instance. But my personal experience is that it's easiest and best for me to take it right before I go to bed. YMMV.
Details about how I take mine
I have to take medications in both the morning and evening, so I'll take my progesterone right after my evening meds. I just grab a glove, some anal lube (I use sliquid sassy), and 2 of my 100mg pills. I put the glove on my right hand, put a healthy amount of lube on my right index finger, get my rectum lubed up inside, then I drop one pill at a time into my right hand (so I don't touch the glove), and then use the fingers on my right hand to pick up the pill between my index finger and thumb, then just pop it in, making sure to push it all the way with my right index finger. Then all I have to do is take off my glove, and head to bed.
(Oh, and taking it at night also means that you don't have to deal with the peak of it, which—for instance—would make me incredibly horny lol)
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