Before asking maybe check the archwiki since most problems usually have solution there.

https://wiki.archlinux.org/title/Discord

Had the exact issue after whatever pipewire update, fixed it by switching to pulseaudio. Was really trying to find different solution, one thing works temporarily(and I mean it, sometimes it fixed the issue for 1 minute sometimes for the entire session) is to switch audio profile to pro mode(if on kde at least)

Sorry not a Linux specific thing but possible a sample rate conflict? If you're able to test/toggle between 48k and 44.1 that might be worth trying.

Ran into a similar problem on Ubuntu a while back, was the sound card being put into power saving mode by default. Maybe worth checking if you can turn off any power savings with your install.

It's probably the pipes, but may also be the wires 😹

I would open up QJackCtl and see if you get and Jack messages, since pipe wire has a jack interface as well. Idk if that actually makes sense, but I would definitely do it. Oh also obviously disable the eq and see if it changes. Wait no not the eq, the effects. Are your headphones Bluetooth?