"Thank you for your thoughts on this matter, I didn't read them. Here is a boilerplate statement espousing all the great things about this bill that you specifically criticized in your message to me. Please don't reach out again."
I honestly think it depends on the Senator.
I've had a really good response from Senator Warnock who ended up sending a representative out to inspect housing filled with black mold and mildew on the military base I work on.
Not sure what actually came of it, but Warnock did do something at least.