Two-handed weapons require two hands, and one-handed weapons require a free hand to load. But you could use a one-handed weapon that you don't have to load. Or rather, you don't even need to do that, since no weapons are listed as being one-handed.

Just have someone carry you around in their pockets, then throw you in the enemies eyes to temporarily blind them.

Still needs an arcane focus and the spell components could be problematic. Monk maybe? (A dextrous pile of dust gently (yet masterfully!) being blown at enemies)