On Earth, the cardinal directions are straightforward. The arrow on a compass points to the nearest magnetic pole. You can then use it to travel anywhere on Earth.
In space, the idea of anything being “central” enough to be used as a “North” (since the universe has no center) or being fixated enough to not somehow pose issues is more convoluted.
If you were a pioneer of space exploration, what would your “North” be?
The sun would be the most obvious choice for such a reference point, though it'd be amusing to make it Greenwich and therefore make everyone deal with Earth's rotation and orbit if they want extremely precise calculations (though I expect there wouldn't really be a practical difference on that scale).