You can use virustotal for any game/file under 650MBs; This meme was created as a joke, good security practices should always be followed.

No anti virus will be 100% accurate, viruses get missed all the time, while legitimate software can acquire false flags.

I would never recommend just running a random .exe you find on the internet with wine as any non-root protected files could potentially be damaged; With Bottles (the application) all files outside of the created bottle are not visible to programs ran/installed inside the bottle.

If you really want to try something, throwing caution to the wind, running it in a wine BOTTLE that's created just for that program, has a low chance of damaging your computer. (This does not mean "safe")