I only gave GNOME a try... so by default I would say KDE Plasma?

Gnome is probably a good choice if you like MacOS' ecosystem and design (maybe also those having touch screens??). But personally I totally hated it... Can't even right click and create a folder/document by default... uggh gives me MacOS PTSD...

KDE plasma is more fitted for those looking for a "Windows" feeling and greater customization.

My personal preference RN is XFCE on EndeavourOS ! Great design, simplicity, elegant, great defaults OOTB...