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Scientists May Have Figured Out How to Make Fat Cells Burn Calories (www.sciencealert.com)
submitted 2 years ago by [M] to c/science@lemmy.world
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'may' is my most despised headline word. This article sounds like they may be onto something in mice trials anyway.

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[–] 8 points 2 years ago (1 child)

Remember that Alli pill a few years back that blocked fat absorption and gave everyone diarrhea?

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  • [–] 1 point 2 years ago (2 children)

    No, but that's essentially what Wegovy/Ozempic does. I'm pretty sure diarrhea is necessary for weight loss (it's not).

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  • [–] 4 points 2 years ago (2 children)

    Nah, ozempic and Co change sugar absorption and satiation. People on it primarily eat way less instantly, apparently they just feel full and don't feel any desire to keep going. It also slows sugar absorption which is why it helps manage diabetes, so that might also play some role

    So far we've found it thickens the intestinal lining and significantly messes with the reward pathways, we're not sure what the long term effects could be. It seems like at best, you basically have to stay on it indefinitely or regain the weight (which is true of current weight loss drugs)

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  • [–] 4 points 2 years ago (1 child)

    It certainly does mess with reward pathways, seems to counteract my antidepressant and Adderall.

    And yeah, I'm aware of the regain weight fun. My insurance currently has a lifetime cap of the benefit. So that will be interesting to see how that plays out. My hope is that the habits I'm forming stick, but I have doubts about that.

    Does the thickening of the intestinal wall contribute to the weird bowl changes? Seems like it either moves extremely fast or takes a week, no in between

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  • [–] 4 points 2 years ago (1 child)

    As for the thickening of the bowel, I have no idea, but it seems like the bowel movement speed and that are both side effects

    And as for making it stick - here's my take. Animals don't become obese... Except when you feed them highly processed food. There's also a theory floating around that seed oils drive sugar cravings, and the fat they release does the same thing

    So my advice would be this - use this opportunity to fix this. If you burn the old fat, get rid of your sugar cravings, and eat better food you might be able to fix your system in a way people mostly only do by moving to somewhere with better food culture for years

    Avoid processed food and seed oils as much as possible. Take advantage of the time you have on it, and stack the deck in your favor while you can

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  • [–] 1 point 2 years ago (1 child)

    Processed food is simple enough to identify just because there is so much of it. I'm not familiar with seed oils so I'll look that up.

    But yeah. The sugar cravings are the hardest part of everything. The Wegovy thankfully limits how much I can consume, but it's still there.

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  • [–] 1 point 2 years ago

    Seed oils are like canola, soy, "vegetable", sunflower, etc. They're the cheapest, so they're used wherever they can be

    As for alternatives, some people say grass fed butter/ghi is the easy to go, personally I mostly use olive oil (although I'm not super clear on why that's different)

    Ultimately, something is very wrong with our diets, and seed oils + sugar are where the experts offering explanations seem to be pointing. There's other things it could be, like micro plastics and the million other containments in our food and water allowed in doses that don't cause obvious harm, and even foods like tomatoes and potatoes that contain toxins (ones that are minimal if you prepare them properly, but we don't prepare them how we used to)

    I definitely recommend researching it, and I'd be interested to hear what you come up with

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