Sure you can. As others have said, a list comprehension returns a new list. See the documentation.
What are you trying to do though? Append a list comprehension to an existing list?
See a modified version of @eager_eagle@lemmy.world's code from their comment.
def double(x):
return 2 * x
a = list(range(10))
a.extend(double(value) for value in range(5))
# a has 15 elements
print(a)