I don't have any direct experience with either of the printers you're referring to, but I have a couple of printers in the Ender 3 series (an Ender 3 pro that I've done some upgrades on and an Ender 3 V2 Neo.)
If you do end up going the Creality direction, I'd definitely recommend something with a CR Touch. I've lived without a CR Touch in the past and once I got my first taste of printing with a CR Touch, I now consider it a must-have.
And in general, I do feel like Creality's great at "plug and play," at least with the Creality machines I have.
Most folks I know who have bought the MK3S got it specifically for the 5-way extruder upgrade.
As for where to put your printer, I have seen some studies that found that PLA is vastly less toxic than basically any of the other filament material options. And what I've read about it has eased my concerns about printing in the same room I sleep in. (And my room's smaller than 30x30. More like 10x12.) Of course, only you can make your own decision on that score, but for what little bit an internet stranger's opinion counts, I don't have any concerns with PLA printing fumes. (Other filaments, no chance I'd print in my bedroom.)