I remember in Revenge of the Sith, when the actor playing Vader yells "nooooooooo", at what is supposed to be the emotional climax of the trilogy, the theater roared in laughter.
It's been decades since I've been to the cinema, so I don't know if this counts, but a recent example I can think of is when I watched No Exit the other day, and laughed really hard both when one bad guy spoiler gets shot with a nail in the forehead by the other and again when he then spoiler fell on his face and drove the nail home, literally ¯\(ツ)/¯