I try to roll with the punches, but I will reload when I get tripped up by not understanding DND things, or when I need an NPC to stay alive. Like, in Act 2, I failed utterly at something and was going to just roll with it, until I saw it caused the death of an NPC I needed for Karlach’s personal quest. So I reloaded again and again until I got it right. (Same with the tower defense section you need to finally recruit Halsin.) I’m not good at the kind of tactical planning you need for fights in this game, so it takes me multiple tries to figure it out.
I won’t reload for bad rolls in conversations, though, even if I completely whiff something with a Nat1. That’s the kind of thing that makes the game replayable for me.