I'm wanting to do a full transition to Linux for audio work, but I couldn't get Wwise to work, even with Wine/Bottles. Just will refuse to install. Identical issue on other people's linux systems.
I also started with Ubuntu Studio, but 90% of the stuff it comes with is irrelevant to pro audio, and it was just running super slow. OpenSUSE Leap works like a charm for everything (except Wwise of course). Though Leap might be getting axed and no longer worked on in the future (nothing is certain yet). So I might also try Debian.
Because Wwise wasn't working, I never got around to testing out all my VSTs though. Have you tried using either Wine or Bottles for them?