Yesbut...

Rust's GUI frameworks are all (afaik) still pretty early and a little clunky to use.

...and compiling for Windows is a little clunky.

From a purely yes/no perspective, you can absolutely use Rust for building desktop GUI apps... But I'd recommend using a different language unless your app has really tight performance requirements.

If you want to make a cross platform app with good GUI support, I'd a actually recommend checking out Godot. It's technically a game engine, but the built in scripting language (gdscript) and GUI components are really great. If gdscript is too slow for your purposes you can swap in a lot of other languages (including Rust) though C# is the best supported of these.