Yeah. Who gets to be a political party isn't written into the constitution; we've had big parties come and go before. It's been stable for so long that it's started to seem like part of the fabric, but it's not.
If the RNC becomes unable to fund or organize any downballot races at all, so that at the end of it all Trump brings about the collapse of the GOP, then I'd be okay with that.
Of course, there's also an option that his seizure and mismanagement of the whole Republican machinery means that they suffer a bloodbath in congress, but he wins the presidency, and then like so many dictators before him he simply declares that congress doesn't count anymore and he's not bound by them, with the supreme court majority behind him and his violent supporters ready to kill to back it up. That's a possibility.
There could be a nice synergy that we could use the collapse of the GOP to enact something like proportional representation in congress, which would be kind of an easy sell at that point if the left wing is okay with it, because it's a way for conservatives to hold on to some level of power instead of none.
But the first possibility is much, much more plausible to me unfortunately