I guess random Windows programs are even safer as they may not really work on the host OS.
But still, Bottles is top tier, it works great and is perfectly packaged as a flatpak (no permissions, portal use etc) and pupgui allows to use the latest protonge.
To Librewolf, that is hosted on their own repo, using their own build system. So it could be considered as less trusted than upstream firefox managed by fedora, especially in terms of timely updates. You could also use the Firefox binary, which is very quick (did a benchmark) but you need to do the desktop entry yourself.
Also Librewolf is not security hardened afaik, maybe a few checks are also for security but it should be the same as Firefox. It is privacy optimized. Disadvantage here again is, that if you need a vanilla profile for shitty websites etc, that doesnt exist.