I don't think the US is a lost cause. I think about 80-90% of the US shouldn't be the focus of smarter urbanization efforts, but that's because 80-90% of the US is sprawling farm land.
I'm seeing sentiment shift around cars, bikes, and public transit. I had a discussion at work the other day and three of five people said they would much prefer public transit or biking to work, it's just not viable with today's options. I think local effort can and will spread the message. "If Springfield can do it, Shelbyville can do it better" needs to be our aim. Things like national high speed rail networks are just too big to start until the ball is already rolling.