Gaming for me is mostly fine on Linux, it’s running Ableton with standard plug-ins that doesn’t work, surprisingly.
Considering that Digital Audio Workstation software requires a special low-latency sound subsystem (including kernel support) to work properly, not being able to correctly run a Windows one in WINE doesn't surprise me in the slightest. Bet it'd work if you switched to something like Audacity or Rosegarden, though (assuming you've got all the PulseAudio/JACK/PipeWire stuff I don't understand set up correctly, anyway).