Maybe it depends on the podcast.
While I think you might be referring to "male enhancement pills" and crap like that, I steer clear of the kind of podcast that would even consider pushing that sort of thing, in fact find that product ecosystem kind of interesting sometimes.
So far from the type of company that advertises in this medium, I've bought underwear, a massage machine for muscle spasms, and a monthly gift box service where I've gotten some very nice articles of clothing.

I mean it's no different than any other form of advertisement. Just do your own research.

Magic Spoon is pretty good though. Although you can buy it at Whole Foods now.