I am from that player generation who played the WOD games in the early 00's. Like nobody around was playing D&D, it was VtM, Dark-age, Werewolf, Eastern-Vampires, Mage, hunter and so on.
These games are greats, the system has a good balance between light and crunchy, the setting is amazing with a shit ton of secret, and the idea of playing power struggles as the apocalypse comes was pretty cool.
That said, these games also have their own issue. A big one is their tendency to behave like D&D with tons of sourcebook. Moreover each sourcebook/game are written by different people leading to contradiction in the lore, not a big deal except when everyone pretends to be an expert on the lore. Another big one is that you sell a game where you play monsters struggling to keep their humanity and political power game, and you end up having a system about killing and fiighting I believe the 5th edition solved some of these problems. A last one is that it's really hard to get player to cooperate, not necessarily a big deal if everyone is aware of it, but there is the point where No, I don't see why I'd play that quest, especially with these people comes to the table.
But still a very great set of games