It's totally doable now. Even compared to when I switched (when Windows 10 came out), it's smoother and easier to transition.
The only real issues are adobe products being a pain in the ass. I don't use them in the first place, but they're a dealbreaker that requires dual booting for some folks.
Anything else mainstream tends to be WINE friendly nowadays. I keep a Windows 7 media computer for my music needs because musicbee is a pain in the ass on Linux, and that's it. Everything else is linux now that's mine.
