I'm very much against voter nihilism regardless of the statistics. Regardless of if I'm getting steam rolled or not, I'm putting pen to paper and I want the record to show that someone didn't agree with the mob - me, it was me. The US is a two party system and personally I think that sucks. You are definitely "throwing your vote away" by conventional wisdom in such a system, but if everyone thinks this way there is no hope for any traction or interest in advancing third parties - so I agree with this form of voter suicide.