For those who are wondering, yes, Wine is malware compatible so be careful about the EXEs you run!

https://wiki.winehq.org/FAQ#Is_Wine_malware-compatible.3F

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[–] 1 point 3 years ago

My personal pick is Nobara (which is fedora but with easy codecs and driver install script). But anything Ubuntu or Fedora bases is going to work great (From what I remember Nobara and POP_OS! Have great Nvidia support out of the box)

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