I'm already on Estradiol monotherapy with sublingual pills. My new dealer wanted to start me on 3mg of Estradiol Cypionate per week. I asked instead for 4mg/week of Estradiol Cypionate which accepted. But per https://transfemscience.org/articles/transfem-intro/ it looks like I should have asked for 5mg of Cypionate weekly to start, and fine tune from there.

Has anybody had success for monotherapy on 4mg/week? The calculators on the website show a mid-slope of 225 pg/mL. For 5mg/week it's 275 pg/mL.