▲ 183 ▼ Grapefruit Redbull (lemmings.world) submitted 5 months ago by GreenDust@lemmings.world to c/lemmyshitpost@lemmy.world 32 comments fedilink hide all child comments
[–] sem@piefed.blahaj.zone 1 point 5 months ago (1 child) Wait... I don't think that's true. If it were, they'd put it in the instructions that come with the SSRI medicines. And it is not on the list of drugs on this web page. https://www.fda.gov/consumers/consumer-updates/grapefruit-juice-and-some-drugs-dont-mix permalink fedilink source parent hideshow 2 child comments replies: [–] GeneralVincent@lemmy.world 4 points 5 months ago* (last edited 5 months ago) (1 child) Yup, I made a bad generalization. My bad, and to be clear I'm not a doctor or anything. Some SSRIs may have an interaction with grapefruit. But grapefruit interacts with different medications differently, and it's not based on the class of medication, it's med specific. e.g. Sertraline (Zoloft) is an SSRI and is listed as having an interaction with grapefruit https://en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_interactions Eta: thanks for calling that out, I've learned some interesting things, for example; Ketamine: After drinking 200 mL of grapefruit juice daily for five days, the overall absorption of orally ingested ketamine was increased three-fold compared to the control group in a clinical trial. The peak blood ketamine concentration was increased over two-fold. permalink fedilink source parent hideshow 2 child comments replies: [–] sem@piefed.blahaj.zone 1 point 5 months ago That is so weird. Here is the study: https://pubmed.ncbi.nlm.nih.gov/10890261/ It was only n=5 but my layperson understanding is that the results were significant. Either I've never noticed a grapefruit warning (and at one time I read the documentation fully) or Sertraline doesn't come with one... permalink fedilink source parent
[–] GeneralVincent@lemmy.world 4 points 5 months ago* (last edited 5 months ago) (1 child) Yup, I made a bad generalization. My bad, and to be clear I'm not a doctor or anything. Some SSRIs may have an interaction with grapefruit. But grapefruit interacts with different medications differently, and it's not based on the class of medication, it's med specific. e.g. Sertraline (Zoloft) is an SSRI and is listed as having an interaction with grapefruit https://en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_interactions Eta: thanks for calling that out, I've learned some interesting things, for example; Ketamine: After drinking 200 mL of grapefruit juice daily for five days, the overall absorption of orally ingested ketamine was increased three-fold compared to the control group in a clinical trial. The peak blood ketamine concentration was increased over two-fold. permalink fedilink source parent hideshow 2 child comments replies: [–] sem@piefed.blahaj.zone 1 point 5 months ago That is so weird. Here is the study: https://pubmed.ncbi.nlm.nih.gov/10890261/ It was only n=5 but my layperson understanding is that the results were significant. Either I've never noticed a grapefruit warning (and at one time I read the documentation fully) or Sertraline doesn't come with one... permalink fedilink source parent
[–] sem@piefed.blahaj.zone 1 point 5 months ago That is so weird. Here is the study: https://pubmed.ncbi.nlm.nih.gov/10890261/ It was only n=5 but my layperson understanding is that the results were significant. Either I've never noticed a grapefruit warning (and at one time I read the documentation fully) or Sertraline doesn't come with one... permalink fedilink source parent
