I've tried a few distros recently (Bazzite, Nobara, Debian...), all with Plasma+Wayland, and none of them work with my Wacom Intuos. Nobara with Gnome works fine (that's what I'm using in the meantime), albeit with a limited feature set: can't remap tablet area, can't use or remap the tablet buttons.
So, I've narrowed it down to something inbetween Plasma and Wayland. That's all I know for now

I use the tablet as a pointing device -using a mouse hurts my wrist after roughly 20mn (old injury). So it really is an accessibility issue...

I have said this a few times before, apologies, but I'm hammering it because it's not notorious enough.