Sequence now lives at collections.abc. BTW, float is not a supertype of int (issubclass(int, float) == False). Normaly, It is acceptable to use int instead of float, but speaking of variance, it is more precise to use numbers.Real:
issubclass(Integral, Real) == True
issubclass(int, Real) == True
issubclass(float, Real) == True
issubclass(complex, Real) == False