Safari + AdGuard used to work on my iPad, but it has recently been blocked with a disable Ad-block message. Orion works for me when I disable all build-in content blocking and using the Firefox version of Ublock Origin.

I think the build-in blocker is too basic and gets detected by YouTube, while ublock works (everywhere I've tested it, desktop, android, iPad)

Thanks for Orion tip, didn’t know that