I mean, ok, I get that, but it's never been an issue for me personally. I've never had a vehicle that hit it's EPA estimate when I drive 85+ with the AC at full blast when it's 105+ outside. My truck is rated for 517 highway and I've never got more than 330 out of a tank, so, it is what it is I guess.
Edit: So I'm saying I assume I'll need 500mi to hit ~350mi, that's always been my base assumption.