He's a culturally significant musician who has released numerous albums and worked with a wide variety of artists, probably most notably David Byrne of Talking Heads.
For example David Bowie's "I'm Afraid of Americans" that he worked on with Trent Reznor originally started as a collaboration between Bowie and Eno. Reznor cleaned it up and made it radio friendly whereas Eno's cut was highly experimental as he is wont to do.
Brian Eno on "scenius":